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Product Description of Arbutin CAS#497-76-7

Arbutin is a glycosylated form of hydroquinone naturally found in Arctostaphylos plants and exhibits a range of biological activities, including tyrosinase inhibition, antioxidant effects, and anti-inflammatory properties. It effectively suppresses human tyrosinase activity in crude enzyme preparations isolated from melanocytes (IC50 values of 5.7 and 18.9 mM using L-tyrosine and L-DOPA as substrates, respectively) as well as in intact melanocytes (IC50 = 0.5 mM).

At a concentration of 50 μM, arbutin inhibits hemolysis induced by the free radical generator AAPH in sheep erythrocytes, and at concentrations above 125 μM, it prevents AAPH-induced reductions in cell viability in cultured human skin fibroblasts. In an LPS-induced rat model of acute lung injury, arbutin (50 mg/kg) suppresses increases in IL-1β, IL-6, and TNF-α levels in both lung tissue and serum. Formulations containing arbutin have been widely applied in the treatment of hyperpigmentation disorders.

Product Application of Arbutin CAS#497-76-7

Arbutin is applied in diuretic and anti-infective medications for the urinary system. It is also used as a stabilizer in color photographic developing processes. In cosmetic formulations, arbutin is widely utilized for skin whitening, freckle reduction, and hair care applications.